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Side Effects of Rosiglitazone and Metformin

There are a number of potential side effects of rosiglitazone and metformin to look out for, including: upset stomach, nausea or vomiting, dizziness, and anemia. Besides these common problems, there are also some potentially serious side effects that could occur. Notify your healthcare provider immediately if you experience any symptoms of high or low blood sugar, rapid weight gain, or signs of an allergic reaction.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and metformin, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and metformin.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

Side Effects of Rosiglitazone and Metformin: An Introduction

As with any medicine, there are possible side effects with rosiglitazone and metformin (Avandamet®). However, not everyone who takes this drug will experience side effects. In fact, most people tolerate it well. When side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(The side effects discussed below are not a complete list of side effects reported with the combination medicine. Your healthcare provider can discuss a more complete list of possible side effects with you.)
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Rosiglitazone and Metformin Info

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