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Rosiglitazone and metformin, a medication available by prescription, is used to treat type 2 diabetes in adults. It helps reduce blood sugar levels by decreasing sugar absorption into the body and improving insulin sensitivity. Rosiglitazone and metformin, which should be used in conjunction with lifestyle changes, comes in a tablet form that is usually taken once or twice a day. The combination drug is not suitable for everyone, so let your healthcare provider know if you have any heart problems, kidney problems, or liver problems.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and metformin, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and metformin.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

What Is Rosiglitazone and Metformin?

Rosiglitazone and metformin (Avandamet®) is a prescription medication that is used to treat type 2 diabetes (also known as noninsulin-dependent diabetes or adult-onset diabetes). The drug is a combination of two different diabetes medications: rosiglitazone maleate (Avandia®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®).
(Click What Is Rosiglitazone and Metformin Used For? for more information on what rosiglitazone and metformin is used for, including possible off-label uses.)
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Last reviewed by: Kristi Monson, PharmD;
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