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Synthroid Drug Interactions

Diabetes Medications
When you first start Synthroid (or increase your dose), your healthcare provider may need to increase the dose of your diabetes medications. Check with your healthcare provider before taking Synthroid if you are already taking diabetes medications.
 
Digoxin
Synthroid can make digoxin less effective, which can be dangerous. Check with your healthcare provider, as your digoxin dose may need to be increased.
 
Estrogens
Estrogens can lower the level of Synthroid in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your Synthroid dose if you start or stop taking an estrogen medication.
 
Iron
Iron can bind to Synthroid in the digestive tract, preventing it from being absorbed into the body. Make sure to separate Synthroid and iron supplements by at least four hours.
 
Orlistat
Orlistat may decrease the absorption of Synthroid into the body. Your healthcare provider should check your thyroid function if you start (or stop) taking orlistat. Your Synthroid dosage may need to be adjusted.
 
Raloxifene
There have been reports that raloxifene may decrease the absorption of Synthroid into the body, although it is not clear if this is a significant drug interaction.
 
Rifampin
Taking Synthroid with rifampin may change the amount of Synthroid your body needs, and your healthcare provider may need to adjust your Synthroid dosage as a result.
 
Sucralfate
Sucralfate can bind to Synthroid in the digestive tract, preventing it from being absorbed into the body. Make sure to separate Synthroid and sucralfate by at least four hours.
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Synthroid Medication Information

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