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Drug Interactions

Sitagliptin is unlikely to interact with most medications (see Drug Interactions With Sitagliptin).

Alternatives to Sitagliptin

In general, treatment for type 2 diabetes begins with lifestyle changes (for example, weight loss, exercise, and diet). If lifestyle changes alone are not effective at managing diabetes, medication such as sitagliptin may be necessary.
The main goal of diabetes medication is to lower blood sugar levels enough to reduce your risk of developing problems related to diabetes, such as heart, nerve, eye, or kidney problems. Because sitagliptin can lower blood sugar levels, people may be able to lower their risk for developing problems related to high blood sugar by taking it.
The drug is quite effective at controlling blood sugar. It is also generally well tolerated. However, side effects can occur, or the medicine may not work as well as needed. In these cases, you may need to combine sitagliptin with another diabetes medicine, such metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). You may also wish to consider a substitute for sitagliptin. These can include other diabetes drugs, either by themselves or in combination.
(Click Januvia Alternatives to learn more.)
To learn about controlling diabetes through lifestyle choices, see the following eMedTV articles:
Common Symptoms of Diabetic Neuropathy

Sitagliptin Phosphate

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