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What Is Sitagliptin and Metformin Extended-Release Used For?

How Does Sitagliptin and Metformin Extended-Release Work?

As mentioned already, sitagliptin and metformin extended-release contains two diabetes medicines, which work in different ways to control blood sugar.
 
Sitagliptin belongs to a group of medicines known as dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down certain hormones known as incretin hormones. These cause insulin to be released from the pancreas in response to meals. They also reduce the amount of glucagon released by the pancreas, which reduces glucose (sugar) production by the liver.
 
By blocking the DPP-4 enzyme, sitagliptin and metformin extended-release increases the level of incretin hormones in the blood. This causes more insulin to be made in response to meals and less glucose to be made by the liver.
 
Metformin belongs to a group of medicines known as biguanides. It lowers blood sugar levels in several ways, such as:
 
  • Decreasing the amount of glucose made by the liver
  • Decreasing the amount of sugar absorbed into the body through the small intestines
  • Improving insulin sensitivity, which helps increase glucose uptake and use by cells.
 
Sitagliptin and metformin extended-release contains the extended-release version of metformin. This drug stays in the body longer than regular metformin, so it only needs to be taken once a day.
 

Can Children Use It?

Sitagliptin and metformin extended-release is only approved for use in adults 18 years of age and older. It has not been adequately studied in individuals younger than this. Talk to your child's healthcare provider about the risks and benefits of using this medication in children.
 

Is It Safe for Older Adults to Use Sitagliptin and Metformin Extended-Release?

Older adults can use this medication. However, sitagliptin and metformin extended-release should only be used in people whose kidneys function normally. Because kidney function naturally declines with age, this medication may not be appropriate for some older adults. Your healthcare provider will check your kidney function before you start sitagliptin and metformin extended-release and periodically during treatment.
 
Type 2 Diabetes: Fact or Fiction

Sitagliptin and Metformin Extended-Release Information

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