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Sitagliptin and Metformin Extended-Release Side Effects

People who take sitagliptin and metformin extended-release may develop side effects, such as headaches, nausea, and common cold symptoms. However, most people handle the medication fairly well, and adverse reactions are generally minor and easy to treat. Serious complications have been reported with this drug, so seek medical treatment if you experience reactions like vomiting, blurred vision, or unexplained swelling.

An Introduction to Side Effects of Sitagliptin and Metformin Extended-Release

Just like any medicine, sitagliptin and metformin extended-release (Janumet® XR) can cause side effects. However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with sitagliptin and metformin extended-release. Your healthcare provider can discuss a more complete list with you.)

Serious Sitagliptin and Metformin Extended-Release Side Effects

Some side effects of sitagliptin and metformin extended-release are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to:
  • Signs of a rare but serious condition known as lactic acidosis, which include:
    • Feeling very weak, tired, or sleepy
    • Unusual muscle pain
    • Unexplained nausea, vomiting, or diarrhea
    • Feelings of coldness, especially in the arms and legs
    • Dizziness or lightheadedness
    • A slow or irregular heartbeat
  • Signs of pancreatitis (inflammation of the pancreas), such as:
    • Abdominal (stomach) pain or tenderness that may radiate to the back
    • Nausea
    • Vomiting
    • Loss of appetite
  • Signs of low blood sugar (hypoglycemia), such as:
    • Shakiness
    • Sweating
    • Hunger
    • Headache
    • Dizziness
    • Confusion
    • Blurry vision
    • Change in mood, such as irritability
    • A fast heartbeat
  • Swelling of the arms, hands, legs, ankles, or feet
  • Decrease in the amount you normally urinate
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching, flaking, or peeling of the skin
    • Unexplained swelling, especially of the face, lips, or throat
    • Difficulty swallowing or breathing.
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Sitagliptin and Metformin Extended-Release Information

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