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Sitagliptin and Metformin Extended-Release Side Effects

Common Side Effects

While sitagliptin and metformin extended-release itself has not been studied in clinical trials, the short-acting version of the medication, Janumet® (sitagliptin and metformin) has been studied. In these studies, the side effects that occurred in a group of people taking this drug were carefully documented and compared to those that occurred in a similar group of people taking either a placebo (a "sugar pill" with no active ingredients) or the individual components of Janumet alone.
As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo or the other medicines. In these studies, the most common reactions included:
  • Diarrhea -- in up to 7.5 percent of people
  • Upper respiratory tract infection (such as the common cold) -- up to 6.2 percent
  • Headache -- up to 5.9 percent
  • Nausea -- up to 4.8 percent
  • Abdominal (stomach) pain -- up to 3 percent
  • Vomiting -- up to 2.2 percent
  • Extremely low blood sugar (hypoglycemia) -- up to 1.6 percent.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any adverse reactions while using the drug or if something "just does not seem right." While it may not be a side effect of sitagliptin and metformin extended-release, your healthcare provider will be able to diagnose and treat the problem.
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Sitagliptin and Metformin Extended-Release Information

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