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Sitagliptin and Metformin Extended-Release

Clinical Effects for Sitagliptin and Metformin Extended-Release

Sitagliptin and metformin extended-release itself has not been studied in clinical trials. However, studies have looked at the effects of the combination of immediate-release metformin and sitagliptin on short-term and long-term blood sugar control. Immediate-release metformin and sitagliptin are the two active medicines contained in regular Janumet.
Sitagliptin and metformin extended-release contains metformin ER. Clinical studies have shown that metformin ER is as effective as immediate-release forms of this medication.
Effects on Hemoglobin A1c
HbA1c is a test used to measure long-term blood sugar control. People without diabetes usually have HbA1c results that are less than 6 percent, while people with diabetes have higher results. Studies have shown that the higher the HbA1c, the greater the chance for developing long-term problems related to diabetes, such as heart, eye, nerve, and kidney problems.
In a clinical study, people who had diabetes that was not well controlled with diet and exercise were able to reduce their HbA1C by 1.4 percent to 1.9 percent, on average, after taking sitagliptin and metformin for 24 weeks. As might be expected, higher doses resulted in greater Hb1Ac reductions. In comparison, people taking metformin alone lowered their HbA1c by 0.8 percent to 1.1 percent, while those taking sitagliptin alone lowered their HbA1c by 0.7 percent.
Effects on Blood Sugar Levels
In the same study, people given metformin with sitagliptin had a lowering of their fasting blood sugar by 47 mg/dL to 64 mg/dL, on average. In comparison, metformin alone lowered fasting blood glucose by 27 mg/dL to 29 mg/dL, on average, and sitagliptin alone by 17 mg/dL, on average. 
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Sitagliptin and Metformin Extended-Release Information

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