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Sitagliptin and Metformin Extended-Release Dosage

People with type 2 diabetes who are taking sitagliptin and metformin extended-release will receive a dosage that is based on how well their blood sugar levels are controlled, other medications they are taking, and other factors. This prescription drug comes in the form of a tablet that is taken once a day, preferably with the evening meal.

An Introduction to Your Dosage of Sitagliptin and Metformin Extended-Release

The dose of sitagliptin and metformin extended-release (Janumet® XR) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How well your blood sugar is controlled
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Sitagliptin and Metformin Extended-Release Dosing Guidelines

As the name implies, sitagliptin and metformin extended-release contains two diabetes medicines: sitagliptin (Januvia®) and metformin ER (Glucophage XR®, Glutametz®, and Fortamet®). The recommended initial dosage for treating type 2 diabetes can vary from person to person, but is generally based on your current dose of sitagliptin or metformin, as follows:
  • If you do not already take metformin, the recommended starting dose is sitagliptin and metformin extended-release 100 mg/1000 mg
  • If you already take metformin, the recommended starting dose is one that provides 100 mg of sitagliptin in combination with your current metformin dose
  • If you currently take regular Janumet (sitagliptin and metformin), it is recommended that you start sitagliptin and metformin extended-release at the same total daily dose, but take it once a day.
Your healthcare provider will choose the most appropriate initial dosage based on your unique situation and then slowly increase the amount, if necessary, to a maximum of 100 mg/2000 mg. Doses are increased slowly to help minimize the risk for stomach upset that can occur initially with metformin.
Dosage adjustments are based on how well you tolerate sitagliptin and metformin extended-release and how well your blood sugar is controlled. Your healthcare provider will check your blood sugar control with regular blood tests, including blood sugar checks you can do at home, and hemoglobin A1C blood tests.
Type 2 Diabetes: Fact or Fiction

Sitagliptin and Metformin Extended-Release Information

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