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Precautions and Warnings With Sitagliptin and Metformin Extended-Release

Sitagliptin and metformin extended-release may increase your risk of pancreatitis, low blood sugar levels, and other problems, so make sure you understand the warnings and precautions before taking it. Your healthcare provider will also ask about your medical history and all other drugs you are taking. People who have problems with their liver, kidneys, or heart may need a different diabetes medication.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking sitagliptin and metformin extended-release (Janumet® XR) if you have:
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure (renal failure)
  • Had pancreatitis (inflammation of the pancreas)
  • Congestive heart failure or other heart problems
  • A history of a heart attack or stroke
  • Gallstones
  • Plans for a surgery or medical procedure, including x-rays or procedures where you will be given an injection of dye or contrast agent
  • A condition called metabolic acidosis or if you have had diabetic ketoacidosis (increased ketones in your blood or urine)
  • Low vitamin B12 levels (pernicious anemia)
  • A history of alcoholism or drink alcohol often
  • Any allergies, including to foods, dyes, or preservatives.
In addition, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
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Sitagliptin and Metformin Extended-Release Information

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