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Drug Interactions With Sitagliptin and Metformin Extended-Release

More Detail on Drug Interactions With Sitagliptin and Metformin Extended-Release

The following sections explain in detail the potentially negative interactions that can occur when sitagliptin and metformin extended-release is combined with any of the drugs listed above.
 
Calcium Channel Blockers
Because calcium channel blockers can increase blood glucose (sugar) levels, taking them with sitagliptin and metformin extended-release could make sitagliptin and metformin extended-release less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dosage, if you start or stop taking a calcium channel blocker. 
 
Carbonic Anhydrase Inhibitors
Taking sitagliptin and metformin extended-release with medications known as carbonic anhydrase inhibitors could increase your risk for lactic acidosis, a potentially serious problem caused by an accumulation of acid in the blood. These medications can be used together, but should be done so with caution.
 
Certain Decongestants
Because certain decongestants can cause high blood glucose levels (hyperglycemia), taking them with sitagliptin and metformin extended-release could make sitagliptin and metformin extended-release less effective. Decongestants are in many cough and cold products, so talk to your healthcare provider or pharmacist before taking any cough or cold medication during your diabetes treatment.
 
Cimetidine and Ranitidine
Taking sitagliptin and metformin extended-release with cimetidine or ranitidine could increase your blood levels of both medications, potentially increasing your risk of side effects. Talk to your healthcare provider about this potential interaction before taking these drugs together.
 
Corticosteroids
Corticosteroids have the potential to cause high blood glucose levels (hyperglycemia), which could make sitagliptin and metformin extended-release less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, if you start or stop taking a corticosteroid. 
 
Digoxin
Taking sitagliptin and metformin extended-release with digoxin could increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may need to monitor you more closely, especially when you first start or stop taking these medicines together.
 
Diuretics
Because diuretics may increase blood glucose (sugar) levels, taking them with sitagliptin and metformin extended-release could make sitagliptin and metformin extended-release less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, if you start or stop taking a diuretic medication.
 
Estrogens
Taking sitagliptin and metformin extended-release with estrogens could make sitagliptin and metformin extended-release less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, especially when starting or stopping an estrogen.
 
Insulin
Both insulin and sitagliptin and metformin extended-release can lower blood sugar levels. Thus, taking these medicines together may increase your risk for dangerously low blood sugar levels (hypoglycemia). Although these medicines may be used together to treat diabetes, this may require more careful blood glucose monitoring. Also, your healthcare provider may need to lower your insulin doagse if you take these drugs together.
 
Insulin Secretogogues
Because insulin secretogogues and sitagliptin and metformin extended-release can both lower blood sugar levels, taking these medicines together may increase your risk for dangerously low blood sugar levels (hypoglycemia). This doesn't mean these drugs cannot be used together. However, your healthcare provider may need to lower your insulin secretogogue dose if you take it with sitagliptin and metformin extended-release, or may recommend you monitor your blood glucose levels more closely.
 
Isoniazid
Because isoniazid may cause high blood glucose levels (hyperglycemia), taking it with sitagliptin and metformin extended-release could make sitagliptin and metformin extended-release less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, if you start or stop taking isoniazid.  
 
Morphine
Taking sitagliptin and metformin extended-release with morphine could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely if you start or stop taking these drugs together. 
 
Niacin
Taking sitagliptin and metformin extended-release with niacin can make sitagliptin and metformin extended-release less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Taking sitagliptin and metformin extended-release with oral contraceptives (birth control pills) could make sitagliptin and metformin extended-release less effective, potentially increasing your risk of high blood sugar (hyperglycemia). Talk to your healthcare provider before taking these drugs together, as you may need to be monitored more closely, especially when starting or stopping the birth control pills.
 
Phenothiazines
Phenothiazine medications may cause high blood sugar (hyperglycemia), and could therefore make sitagliptin and metformin extended-release less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, especially when you start or stop taking a phenothiazine.  
 
Phenytoin
Phenytoin may cause high blood sugar (hyperglycemia), and could therefore make sitagliptin and metformin extended-release less effective. You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, especially if you start or stop taking phenytoin.  
 
Procainamide
Taking sitagliptin and metformin extended-release with procainamide could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely, especially when you first start or stop taking these medications together.
 
Quinidine
Taking sitagliptin and metformin extended-release with quinidine could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely, especially if you start or stop taking these drugs together.
 
Quinine
Taking sitagliptin and metformin extended-release with quinine could increase the level of both medicines in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely, especially if you start or stop taking these medications together.
 
Thyroid Medications
Taking sitagliptin and metformin extended-release with thyroid medications can make sitagliptin and metformin extended-release less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your sitagliptin and metformin extended-release dose, especially when starting or stopping a thyroid medication.
 
Trimethoprim
Taking trimethoprim with sitagliptin and metformin extended-release could increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together, especially when first starting or stopping either one.
 
Vancomycin
Taking vancomycin with sitagliptin and metformin extended-release could increase the level of both medications in your blood, potentially increasing your risk of side effects. Your healthcare provider may choose to monitor you more closely if you take these medicines together, especially when first starting or stopping either one.
 
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Sitagliptin and Metformin Extended-Release Information

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