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Side Effects of Saxagliptin/Metformin ER

Although most people have no problems with saxagliptin/metformin ER, serious side effects are possible. For example, if you experience unexplained wheezing, blurry vision, loss of coordination, or seizures while taking it, contact your healthcare provider right away. Fortunately, in most cases, if side effects occur, they are usually mild and easily treated.

An Introduction to Saxagliptin/Metformin ER Side Effects

As with any medicine, side effects are possible with saxagliptin/metformin ER (Kombiglyze™ XR). However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with this drug. Your healthcare provider can discuss a more complete list with you.)

Side Effects of Saxagliptin/Metformin ER to Report

Some saxagliptin/metformin ER side effects are potentially serious and should be reported to your healthcare provider. These include but are not limited to:
  • Symptoms of low blood sugar (which is more likely to occur if saxagliptin/metformin ER is taken with other diabetes drugs), such as:
    • Sweating
    • Shakiness
    • Extreme hunger
    • Dizziness
    • Cold sweats
    • Blurry vision
    • Changes in behavior, such as irritability
    • Loss of coordination
    • Difficulty speaking
    • Confusion
    • Seizures
  • Signs of lactic acidosis (see Metformin and Lactic Acidosis), such as:
    • Feeling tired or weak
    • Muscle pain
    • Trouble breathing
    • Stomach pain
    • Feeling cold
    • Dizziness or lightheadedness
    • Slow or irregular heartbeat


  • Signs of pancreatitis (inflammation or infection of the pancreas), such as:
    • Nausea
    • Vomiting
    • Loss of appetite
    • Severe, persistent abdominal (stomach) pain that sometimes radiates to the back 
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling (especially of the lips, mouth, or throat)
    • Wheezing or other breathing problems.
Healthy Eating for People With Diabetes

Saxagliptin/Metformin ER Drug Information

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