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Saxagliptin/Metformin ER

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to taking saxagliptin/metformin ER if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • An alcohol problem
  • An upcoming radiology procedure that will require the use of contrast dye
  • Pernicious anemia
  • Ever had pancreatitis (inflammation or infection of the pancreas
  • Type 1 diabetes
  • Diabetic ketoacidosis
  • Any allergies, including to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
Make sure to tell your healthcare provider about all of the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Saxagliptin/Metformin ER to learn more, including information on who should not take the drug.)

How Does It Work?

Saxagliptin/metformin ER contains two different kinds of diabetes medication. Saxagliptin is part of a class of drugs called dipeptidyl peptidase-4 (DPP-4) inhibitors. DPP-4 is an enzyme that breaks down incretin hormones.
As a DPP-4 inhibitor, saxagliptin slows down the breakdown of incretin hormones, increasing the level of these hormones in the body. It is this increase that is responsible for the beneficial actions of saxagliptin, including increasing insulin production in response to meals and decreasing the amount of glucose (sugar) that the liver produces.
Because incretin hormones are more active in response to higher blood sugar levels and are less active in response to low blood sugar, the risk of dangerously low blood sugar (hypoglycemia) is low with saxagliptin.
Saxagliptin/metformin ER also contains metformin, a biguanide medication. Metformin works in several ways. It decreases the amount of sugar the liver makes. Metformin can also decrease the amount of sugar absorbed into the body from the diet and can make insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels and better control.
Diabetes Tips for Seniors

Saxagliptin/Metformin ER Drug Information

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