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Saxagliptin/Metformin ER Dosage

Various factors affect the dose of saxagliptin/metformin ER that you are prescribed; however, the usual amount when starting treatment is 5 mg/500 mg. Swallow the tablets whole -- do not crush, break, or chew this medication. Your dosage may be lower than this if you are taking certain drugs that are known to interact with saxagliptin/metformin ER.

An Introduction to Dosing With Saxagliptin/Metformin ER

The dose of saxagliptin/metformin ER (Kombiglyze™ XR) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How well your diabetes is controlled
  • Other medications you are currently taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Saxagliptin/Metformin ER Dosage

The recommended starting dose of saxagliptin/metformin ER for treating type 2 diabetes in most adults is 5 mg/500 mg once daily with the evening meal. If you are switching from saxagliptin (Onglyza™) or one of the many metformin products, your healthcare provider will choose a starting dosage based on your current dose of saxagliptin and/or metformin.
Some medications increase the level of saxagliptin in the bloodstream. For people taking these medications, the recommended saxagliptin/metformin ER dosage is 2.5 mg/1000 mg once daily with the evening meal (see Drug Interactions With Saxagliptin/Metformin ER for more information).

General Information on Taking Saxagliptin/Metformin ER

Some considerations to keep in mind during treatment with saxagliptin/metformin ER include the following:
  • Saxagliptin/metformin ER comes in tablet form. It is taken by mouth once a day with the evening meal.
  • Swallow the tablets whole; never chew, crush, break, or dissolve them.
  • For the medication to work properly, it must be taken as prescribed.
  • If you are unsure about anything related to your dosage or saxagliptin/metformin ER dosing in general, please talk with your doctor, nurse, or pharmacist.
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Saxagliptin/Metformin ER Drug Information

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