Drug Interactions With Saxagliptin/Metformin ER

Calcium channel blockers, digoxin, certain antibiotics, and protease inhibitors are among the drugs that can interact with saxagliptin/metformin ER. In order to prevent problems and ensure the effectiveness of all medications, your healthcare provider may adjust your dosages or monitor you more carefully.

An Overview of Saxagliptin/Metformin ER Interactions

Saxagliptin/metformin ER (Kombiglyze™ XR) can potentially interact with several other medications. Some of these drugs that may lead to reactions with saxagliptin/metformin ER include:
 
 
  • Certain antibiotics or antifungal medications, such as:
     
 
 
  • Cimetidine (Tagamet®)
  • Corticosteroids, such as:
     
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
 
 
 
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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