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Drug Interactions With Saxagliptin/Metformin ER

Isoniazid
Taking saxagliptin/metformin ER with isoniazid can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dose, especially when starting or stopping isoniazid.
 
Nefazodone
Because nefazodone may increase the level of saxagliptin/metformin ER in the bloodstream, a lower saxagliptin/metformin ER dosage (2.5 mg/1000 mg daily) is usually recommended for use in combination with nefazodone. Check with your healthcare provider before taking these medicines together.
 
Niacin
Taking saxagliptin/metformin ER with niacin can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Combining saxagliptin/metformin ER with oral contraceptives (birth control pills) can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Taking saxagliptin/metformin ER with phenothiazines can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dose, especially when starting or stopping a phenothiazine.
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Saxagliptin/Metformin ER Drug Information

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