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Drug Interactions With Saxagliptin/Metformin ER

Cimetidine
Taking saxagliptin/metformin ER with cimetidine can increase the level of saxagliptin/metformin ER in your blood, increasing your risk of side effects. Your healthcare provider may need to adjust your dose of these medications or may suggest an alternative to cimetidine.
 
Corticosteroids
Taking saxagliptin/metformin ER with corticosteroids can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dose, especially when starting or stopping a corticosteroid.
 
Digoxin
Taking digoxin and saxagliptin/metformin ER together may affect the level of both medications in your blood. Your healthcare provider should monitor the level of digoxin in your blood, especially when starting or stopping saxagliptin/metformin ER.
 
Diuretics
Combining saxagliptin/metformin ER with diuretics can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dose, especially when starting or stopping a diuretic.
 
Taking saxagliptin/metformin ER with furosemide, which is a diuretic, can affect the levels of both medications in your blood. This may increase your risk of saxagliptin/metformin ER side effects and may make furosemide less effective. Your healthcare provider may need to adjust your doses of these medications to prevent this interaction.
 
Estrogens
Taking saxagliptin/metformin ER with estrogens can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dose, especially when starting or stopping an estrogen.
7 Signs of High Blood Sugar

Saxagliptin/Metformin ER Drug Information

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