Drug Interactions With Saxagliptin/Metformin ER
More Information on Drug Interactions With Saxagliptin/Metformin ERThe following sections explain in detail the potentially serious reactions that can occur when saxagliptin/metformin ER is combined with any of the drugs listed above.
Calcium Channel Blockers
Taking saxagliptin/metformin ER with calcium channel blockers can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your saxagliptin/metformin ER dosage, especially when starting or stopping a calcium channel blocker.
However, taking saxagliptin/metformin ER with nifedipine, which is a calcium channel blocker, can also increase the level of metformin (one of the components of saxagliptin/metformin) in your blood. Your healthcare provider may need to adjust your dose of saxagliptin/metformin ER to prevent this drug interaction.
Certain Antibiotics or Antifungals
Some antibiotics and antifungals may increase the level of saxagliptin/metformin ER in the bloodstream. As a result, a lower saxagliptin/metformin ER dosage (2.5 mg /1000 mg once daily) is usually recommended for people in such situations. Check with your healthcare provider before combining saxagliptin/metformin ER with such antibiotics or antifungals.
Taking saxagliptin/metformin ER with certain decongestants can make saxagliptin/metformin ER less effective, increasing your chance of high blood sugar (hyperglycemia). Decongestants are in many cough and cold products, so talk to your healthcare provider before taking any cough or cold products if you are taking saxagliptin/metformin ER.
Certain Protease Inhibitors
Some protease inhibitors may increase the level of saxagliptin/metformin ER in the bloodstream. In most cases, a lower dosage of saxagliptin/metformin ER (2.5 mg/1000 mg daily) is recommended for use in combination with these protease inhibitors. Be sure to check with your healthcare provider before combining these drugs.