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Side Effects of Rosiglitazone

Common Rosiglitazone Side Effects

Rosiglitazone has been studied thoroughly in clinical trials, with many people having been evaluated. In these studies, the side effects occurring in a group of people taking the drug are always documented and compared to side effects that occur in a similar group of people not taking the medicine. Based on these studies, the most common rosiglitazone side effects include:
  • Upper respiratory infections (similar to the common cold) -- occurring in up to 9.9 percent of people
  • Broken bones in women (especially in the arm, hand, or foot) -- up to 9.3 percent of women
  • Injury -- in up to 7.6 percent
  • Headache -- in up to 5.6 percent
  • Swelling or water weight gain (edema) -- in up to 4.8 percent (see Avandia and Weight Gain)
  • Back pain -- in up to 4 percent
  • Anemia -- in up to 1.9 percent.
(Click Lipid Effects of Avandia for more information about other possible rosiglitazone side effects.)

Rosiglitazone Side Effects to Report

There are a number of less common (but more serious) side effects with rosiglitazone that you should immediately report to your healthcare provider. These include, but are not limited to:
  • Symptoms of high blood sugar, including:


    • Increased hunger
    • Increased thirst
    • Increased urination
    • Blurred vision
    • Fatigue
    • Shortness of breath
    • Nausea or vomiting


  • Symptoms of low blood sugar, including:


    • Sweating
    • Shakiness
    • Extreme hunger
    • Dizziness
    • Cold sweats
    • Blurry vision
    • Changes in behavior, such as irritability
    • Loss of coordination
    • Difficulty speaking
    • Confusion
    • Seizures


  • Trouble breathing (it may be a sign of new or worsening congestive heart failure)
  • Swelling, especially in the legs or ankles
  • Rapid increase in weight (three to five pounds in less than one week)
  • Liver problems, including:


    • Nausea or vomiting
    • Stomach pain
    • Unusual or unexplained tiredness
    • Loss of appetite
    • Dark urine
    • Yellowing of your skin or the whites of your eyes


  • Vision changes 
  • Signs of an allergic reaction, including an unexplained skin rash, itching, hives, wheezing or trouble breathing, or unexplained swelling.
Diabetes Tips for Seniors

Rosiglitazone Maleate

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