Drug Interactions With Rosiglitazone

As with any medication, there are potential drug interactions with rosiglitazone. Taking rosiglitazone with other medications, such as seizure medications, atazanavir, and gemfibrozil, can increase or decrease the amount of rosiglitazone in your blood. As a result, some of these drug interactions can potentially increase your risk of side effects or decrease the effectiveness of rosiglitazone.

 

An Overview of Rosiglitazone Drug Interactions

Rosiglitazone maleate (Avandia®) can potentially interact with a few drugs. Some of the drugs that can lead to rosiglitazone interactions include:
 

 

  • Certain seizure medications, including:
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)

 

  • Rifampin (Rifadin®) or rifapentine (Priftin®)

 

Rosiglitazone Drug Interactions Explained

 
Atazanavir (Reyataz)
Taking rosiglitazone with atanazavir can increase the level of rosiglitazone in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of rosiglitazone.
 
Certain Seizure Medications
Taking rosiglitazone with certain seizure medications can decrease the level of rosiglitazone in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of rosiglitazone.
(Drug Interactions With Rosiglitazone Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;