Drug Interactions With Rosiglitazone

As with any medication, there are potential drug interactions with rosiglitazone. Taking rosiglitazone with other medications, such as seizure medications, atazanavir, and gemfibrozil, can increase or decrease the amount of rosiglitazone in your blood. As a result, some of these drug interactions can potentially increase your risk of side effects or decrease the effectiveness of rosiglitazone.

Rosiglitazone Maleate

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of rosiglitazone, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take rosiglitazone.

An Overview of Rosiglitazone Drug Interactions

Rosiglitazone maleate (Avandia^®) can potentially interact with a few drugs. Some of the drugs that can lead to rosiglitazone interactions include:

Atazanavir (Reyataz^®)
Certain seizure medications, including:

Carbamazepine (Tegretol^®)
Fosphenytoin (Cerebyx^®)
Phenobarbital (Luminal^®)
Phenytoin (Dilantin^®)
Primidone (Mysoline^®)

Gemfibrozil (Lopid^®)
Insulin
Rifampin (Rifadin^®) or rifapentine (Priftin^®)
Ritonavir (Norvir^®).

Rosiglitazone Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when rosiglitazone is combined with any of the drugs listed above.

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