Side Effects of Rosiglitazone and Metformin

There are a number of potential side effects of rosiglitazone and metformin to look out for, including: upset stomach, nausea or vomiting, dizziness, and anemia. Besides these common problems, there are also some potentially serious side effects that could occur. Notify your healthcare provider immediately if you experience any symptoms of high or low blood sugar, rapid weight gain, or signs of an allergic reaction.

 

Side Effects of Rosiglitazone and Metformin: An Introduction

As with any medicine, there are possible side effects with rosiglitazone and metformin (Avandamet®). However, not everyone who takes this drug will experience side effects. In fact, most people tolerate it well. When side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
 
(The side effects discussed below are not a complete list of side effects reported with the combination medicine. Your healthcare provider can discuss a more complete list of possible side effects with you.)
 

Common Side Effects With Rosiglitazone and Metformin

Rosiglitazone and metformin has been studied thoroughly in clinical trials in which side effects of a group of people taking the drug are documented and compared to another group not taking the medicine.
 
Based on these studies, the most common side effects of rosiglitazone and metformin include:
 
  • Nausea or vomiting -- in up to 16 percent of people
  • Upper respiratory tract infections (similar to the common cold) -- up to 16 percent
  • Diarrhea -- up to 14 percent
  • Headache -- up to 11 percent
  • Upset stomach or heartburn -- up to 10 percent
  • Dizziness -- up to 8 percent
  • Injury -- up to 8 percent
  • Anemia -- up to 7.1 percent
  • Sinus infection or irritation -- up to 6.2 percent
  • Fluid retention or water weight gain and swelling (edema) -- up to 6 percent (see Avandamet and Weight Gain)
  • Abdominal pain (or stomach pain) -- up to 6 percent.
     
Other common side effects of this drug (occurring in 1 percent to 6 percent of people) include:
 

 

Also, a recent study found that up to 9.3 percent of women taking Avandia® (rosiglitazone) develop broken bones -- especially of the arms, hands, or feet. Since rosiglitazone is one of the components of rosiglitazone and metformin, it is possible that women taking Avandamet may also be at risk for broken bones.

 

(Side Effects of Rosiglitazone and Metformin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;