Rosiglitazone and Metformin

Rosiglitazone and Metformin Info

How Does Rosiglitazone and Metformin Work?

Rosiglitazone and metformin is a combination of two diabetes medicines (rosiglitazone and metformin). These two medications work differently and have different effects in the body:

Rosiglitazone is part of a class of diabetes medication called thiazolidinediones (or sometimes called "glitazones"). The drug helps to improve insulin sensitivity. This means that rosiglitazone helps your body respond to insulin better, which helps to lower blood sugar.
Metformin works in several ways. It decreases the amount of sugar (glucose) made by the liver. Metformin can also decrease the amount of sugar absorbed into the body (from the diet) and can make insulin receptors more sensitive, helping the body respond to its own insulin better. All of these effects cause a decrease in blood sugar levels.

Because rosiglitazone and metformin does not increase the amount of insulin the body produces, it is less likely to cause dangerously low blood sugar (hypoglycemia), as many other diabetes drugs can do (see Avandamet Alternatives and Avandamet and Blood Sugar for more information). Rosiglitazone and metformin is not intended to be used for the treatment of type 1 diabetes (see Avandamet and Type 1 Diabetes for more information).

Rosiglitazone and Metformin Effects

There have been several studies looking at the effects of rosiglitazone and metformin on type 2 diabetes:

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