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Rosiglitazone and Metformin Dosage

For people who have not taken either metformin or rosiglitazone prior to starting the combination drug rosiglitazone and metformin, dosage recommendations typically start at 2 mg/500 mg once or twice a day. The recommended starting dosage for those who are replacing their existing metformin or rosiglitazone prescription with the combination medication will vary from person to person, depending on how much medicine was previously taken.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and metformin, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and metformin.
 
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
 

Rosiglitazone and Metformin Dosing: An Introduction

Rosiglitazone and metformin (Avandamet®) is a combination of two different diabetes drugs: rosiglitazone maleate (Avandia®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). The dose of rosiglitazone and metformin that your healthcare provider prescribes will vary depending on a number of factors, including:
 
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you may currently be taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 
7 Signs of High Blood Sugar

Rosiglitazone and Metformin Info

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