Rosiglitazone and Metformin Dosage

For people who have not taken either metformin or rosiglitazone prior to starting the combination drug rosiglitazone and metformin, dosage recommendations typically start at 2 mg/500 mg once or twice a day. The recommended starting dosage for those who are replacing their existing metformin or rosiglitazone prescription with the combination medication will vary from person to person, depending on how much medicine was previously taken.

Rosiglitazone and Metformin Dosing: An Introduction

Rosiglitazone and metformin (Avandamet®) is a combination of two different diabetes drugs: rosiglitazone maleate (Avandia®) and metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Riomet®). The dose of rosiglitazone and metformin that your healthcare provider prescribes will vary depending on a number of factors, including:
 
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you may currently be taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

General Rosiglitazone and Metformin Dosage

For people who are first starting type 2 diabetes treatment with rosiglitazone and metformin, the starting dose is 2 mg/500 mg once or twice a day. Your healthcare provider may increase your dose slowly (up to a maximum of 8 mg/2000 mg total per day) if necessary.
 

Rosiglitazone and Metformin Dosage for People Switching From Metformin

For people switching to rosiglitazone and metformin from just metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, or Riomet), the dose depends on the current metformin dose. For people taking 1000 mg of metformin total per day, the recommended starting dose of rosiglitazone and metformin is 2 mg/500 mg twice daily. For people taking 2000 mg of metformin total per day, the recommended starting dose is 2 mg/1000 mg twice daily. Your healthcare provider may increase your dose slowly up to 8 mg/2000 mg total per day if needed.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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