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Precautions and Warnings With Rosiglitazone and Metformin

Prior to starting a new medication, it is important to be aware of its precautions and warnings. With rosiglitazone and metformin, these precautions include checking your liver enzymes regularly, looking out for signs of extremely low or high blood sugar, and watching for rapid weight gain. Certain people should avoid using rosiglitazone and metformin altogether, including those who are seriously dehydrated, have metabolic or diabetic ketoacidosis, or have kidney disease.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and metformin, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and metformin.
 
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
 

Rosiglitazone and Metformin: What Should I Tell My Healthcare Provider?

Prior to taking rosiglitazone and metformin (Avandamet®), you should talk with your healthcare provider if you have:
 
  • Heart problems of any kind, especially congestive heart failure (CHF)
  • Had a heart attack or stroke
  • Liver problems, including liver failure or cirrhosis
  • Low vitamin B12 levels (pernicious anemia)
  • Kidney problems, including kidney failure (renal failure)
  • An upcoming surgery or procedure (including x-rays and other radiology procedures)
  • Any allergies, including allergies to food, dyes, or preservatives.
     
Also, let your healthcare provider know if you:
 
  • Are pregnant or thinking of becoming pregnant (see Avandamet and Pregnancy)
  • Are breastfeeding
  • Are having problems getting pregnant
  • Are premenopausal without regular menstrual periods
  • Drink alcohol.
     
Also, tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
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Rosiglitazone and Metformin Info

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