Drug Interactions With Rosiglitazone and Metformin

It is important to know that certain medications can cause drug interactions with rosiglitazone and metformin, so tell your healthcare provider about all other medicines you may be taking prior to starting the diabetes drug. Medications that may potentially lead to interactions with this drug include: isoniazid, rifampin, niacin, and calcium channel blockers. Drug interactions can make the medicines less effective, increase medicine levels in your blood, or cause high blood sugar.

 

Rosiglitazone and Metformin Drug Interactions: An Overview

Rosiglitazone and metformin (Avandamet®) can potentially interact with several medicines. Some of the medicines that can interact with this drug include:
 
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or pseudoephedrine (Sudafed®)
     
  • Certain seizure medications, including
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®)
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
o Promethazine (Phenergan®)
(Drug Interactions With Rosiglitazone and Metformin Continued: Page 2)
Add this article to your Favorites     Email this article     Print
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;