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Drug Interactions With Rosiglitazone and Metformin

It is important to know that certain medications can cause drug interactions with rosiglitazone and metformin, so tell your healthcare provider about all other medicines you may be taking prior to starting the diabetes drug. Medications that may potentially lead to interactions with this drug include: isoniazid, rifampin, niacin, and calcium channel blockers. Drug interactions can make the medicines less effective, increase medicine levels in your blood, or cause high blood sugar.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and metformin, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and metformin.
 
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
 

Rosiglitazone and Metformin Drug Interactions: An Overview

Rosiglitazone and metformin (Avandamet®) can potentially interact with several medicines. Some of the medicines that can interact with this drug include:
 
 
 
 
 
 
    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®)
 
  • Diuretics, such as:
 
 
 
 
 
 
Common Symptoms of Diabetic Neuropathy

Rosiglitazone and Metformin Info

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