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Drug Interactions With Rosiglitazone and Metformin

Niacin (nicotinic acid, Niaspan, Niacor, Nicolar)
Taking rosiglitazone and metformin with niacin can make the diabetes drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping niacin.
  
Oral Contraceptives
Taking rosiglitazone and metformin with oral contraceptives (birth control pills) can make the combination drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Taking rosiglitazone and metformin with phenothiazines can make the diabetes drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping a phenothiazine.
 
Rifampin (Rifadin) or Rifapentine (Priftin)
Taking rosiglitazone and metformin with rifampin or rifapentine can decrease the level of the combination medication in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of rosiglitazone and metformin.
 
Ritonavir (Norvir)
Taking rosiglitazone and metformin with ritonavir can increase the level of the combination drug in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of rosiglitazone and metformin.
 
Thyroid Medications
Taking rosiglitazone and metformin with thyroid medications can make the diabetes drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping a thyroid medication.
 
Common Symptoms of Diabetic Neuropathy

Rosiglitazone and Metformin Info

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