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Drug Interactions With Rosiglitazone and Metformin

Corticosteroids
Taking rosiglitazone and metformin with corticosteroids can make the diabetes drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping a corticosteroid.
 
Diuretics
Taking rosiglitazone and metformin with diuretics can make the diabetes drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping a diuretic.
 
Taking rosiglitazone and metformin with furosemide (a diuretic) can affect the levels of both furosemide and the combination drug in your blood. This may increase your risk of side effects and may make furosemide less effective. Your healthcare provider may need to adjust your dose of these medications.
 
Estrogens
Taking rosiglitazone and metformin with estrogens can make the diabetes drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping an estrogen.
 
Gemfibrozil (Lopid)
Taking rosiglitazone and metformin with gemfibrozil can increase the level of the combination medicine in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of rosiglitazone and metformin.
 
Insulin
In studies, people taking rosiglitazone (one of the components of this medication) and insulin had an increased risk of congestive heart failure (CHF) or heart attacks. In general, it is not recommended to combine this medication with insulin.
  
Isoniazid
Taking rosiglitazone and metformin with isoniazid can make the diabetes drug less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and metformin dose, especially when starting or stopping isoniazid.
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Rosiglitazone and Metformin Info

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