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What Is Rosiglitazone and Glimepiride Used For?

Some people may wonder, "What is rosiglitazone and glimepiride used for?" The drug is used to improve the way your body uses its natural insulin and also to cause the pancreas to produce more insulin. Because the drug has not been adequately studied in children, rosiglitazone and glimepiride is currently only recommended for adults.

What Is Rosiglitazone and Glimepiride Used For?

Rosiglitazone and glimepiride (Avandaryl®) is a prescription medication that is used to treat type 2 diabetes. The drug is a combination of two different diabetes medications: rosiglitazone maleate (Avandia®) and glimepiride (Amaryl®).
Rosiglitazone and glimepiride is not used to treat type 1 diabetes.
In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and glimepiride, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and glimepiride.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

Using Rosiglitazone and Glimepiride for Type 2 Diabetes

Type 2 diabetes is the most common type of diabetes (see Diabetes Types). It is also sometimes called adult-onset diabetes or noninsulin-dependent diabetes. Type 2 diabetes is a condition involving insulin resistance. With insulin resistance, the cells of the body do not respond to insulin as well as they normally should. As a result, the cells do not take sugar out of the blood very well. This is why type 2 diabetics have high blood sugar.
Over time, high blood sugar can lead to a number of problems, including diabetic impotence, diabetic neuropathy, kidney failure, and heart disease (see Diabetes Complications). The cause of type 2 diabetes is not fully understood, although it is known that obesity and genetics play an important role.
Rosiglitazone and glimepiride is used for treating type 2 diabetes in people who cannot lower blood sugar through lifestyle changes (such as weight loss, diet, and exercise).
This medication is a combination of two different diabetes drugs (rosiglitazone and glimepiride). These two drugs work differently and have different effects in the body:
  • Rosiglitazone is part of a group of medications called thiazolidinediones (or sometimes called "glitazones"). Rosiglitazone helps to improve insulin sensitivity, meaning that it helps your body to use its natural insulin better. This helps to lower blood sugar and keep it under better control.
  • Glimepiride is part of a class of diabetes medications known as sulfonylureas (see Avandaryl Alternatives). As a sulfonylurea, glimepiride helps the pancreas to produce more insulin. Glimepiride may also help the cells of the body respond better to insulin. Because of these effects, blood sugar levels decrease.


Healthy Eating for People With Diabetes

Rosiglitazone and Glimepiride Drug Info

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