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Side Effects of Rosiglitazone and Glimepiride

As with any medication, there are potential side effects of rosiglitazone and glimepiride, including headaches, low blood sugar, and fluid retention. Most people, however, tolerate the medication well. When side effects do occur, they are generally minor. If you experience more serious side effects, such as trouble breathing, a rapid increase in weight, or vision changes, you should report them immediately to your healthcare provider.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and glimepiride, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and glimepiride.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

Rosiglitazone and Glimepiride Side Effects: An Introduction

As with any medicine, there are possible side effects with rosiglitazone and glimepiride (Avandaryl®). However, not everyone who takes this drug will experience side effects. In fact, most people tolerate the drug well. When side effects do occur, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(The side effects discussed below are not a complete list of side effects reported with rosiglitazone and glimepiride. Your healthcare provider can discuss a more complete list of possible effects with you.)
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Rosiglitazone and Glimepiride Drug Info

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