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Side Effects of Rosiglitazone and Glimepiride

Common Rosiglitazone and Glimepiride Side Effects

This drug has been thoroughly studied in clinical trials in which the side effects reported by a group of people taking the drug are documented and compared to another group not taking the medicine. Based on these studies, the most common side effects of rosiglitazone and glimepiride include:


Also, a recent study found that up to 9.3 percent of women taking Avandia® (rosiglitazone) develop broken bones -- especially of the arms, hands, or feet. Since rosiglitazone is one of the components of rosiglitazone and glimepiride, it is possible that women taking this drug may also be at risk for broken bones.


Rosiglitazone and Glimepiride Side Effects to Report

There are a number of less common (but more serious) side effects of rosiglitazone and glimepiride that you should report to your healthcare provider. These include, but are not limited to:
  • Symptoms of high blood sugar, including:


    • Increased hunger
    • Increased thirst
    • Increased urination
    • Blurred vision
    • Fatigue
    • Shortness of breath
    • Nausea or vomiting 


  • Symptoms of low blood sugar, including:


    • Sweating
    • Shakiness
    • Extreme hunger
    • Dizziness
    • Cold sweats
    • Blurry vision
    • Changes in behavior, such as irritability
    • Loss of coordination
    • Difficulty speaking
    • Confusion
    • Seizures 


  • Trouble breathing (which may be a sign of new or worsening congestive heart failure)  
  • Swelling, especially in the legs or ankles
  • Chest pain, jaw pain, or other heart attack symptoms
  • Rapid increase in weight (three to five pounds or more in less than one week) 
  • Liver problems, including:


    • Nausea or vomiting
    • Stomach pain
    • Unusual or unexplained tiredness
    • Loss of appetite
    • Dark urine
    • Yellowing of your skin or the whites of your eyes


  • Vision changes  
  • Signs of an allergic reaction, including an unexplained skin rash, itching, hives, wheezing or trouble breathing, or unexplained swelling.
Healthy Eating for People With Diabetes

Rosiglitazone and Glimepiride Drug Info

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