A healthcare provider may prescribe rosiglitazone and glimepiride to help lower blood sugar levels in people with type 2 diabetes. This medication works by improving insulin sensitivity and by causing the pancreas to produce more insulin. As with any drug, there are potential side effects that can develop, including headache, low blood sugar, and sore throat. Rosiglitazone and glimepiride comes in the form of a tablet that is generally taken once a day.

• Rosiglitazone is part of a group of medications called thiazolidinediones (or sometimes called "glitazones"). Rosiglitazone helps to improve insulin sensitivity, meaning that it helps your body to use its natural insulin better. This helps to lower blood sugar and keep it under better control.
   
• Glimepiride is part of a class of diabetes medications known as sulfonylureas. As a sulfonylurea, glimepiride helps the pancreas to produce more insulin. Glimepiride may also help the cells of the body respond to insulin better. Because of these effects, blood sugar levels decrease.