Rosiglitazone and Glimepiride Dosage

The usual starting rosiglitazone and glimepiride dosage is 4 mg/1 mg once daily with the first meal of the day. However, the dosage your healthcare provider prescribes will vary depending on a number of factors, such as other medications you may be taking. Your healthcare provider may slowly increase your dosage if necessary. The maximum dose of rosiglitazone and glimepiride is 8 mg/4 mg once daily.

 

Rosiglitazone and Glimepiride Dosing: An Introduction

Rosiglitazone and glimepiride (Avandaryl®) is a combination of two different diabetes drugs: rosiglitazone maleate (Avandia®) and glimepiride (Amaryl®). Your healthcare provider will recommend a dosage based on a number of factors, including:
 
  • How well your diabetes is controlled
  • Other medical conditions you may have
  • Other medications you may currently be taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 

Rosiglitazone and Glimepiride Dosing for Type 2 Diabetes

The recommended starting dose of this medication is rosiglitazone and glimepiride 4 mg/1 mg once daily with the first meal of the day. If you are switching from rosiglitazone (Avandia) or glimepiride (Amaryl), the starting dose can be as high as rosiglitazone and glimepiride 4 mg/2 mg once daily. If you are already taking both Avandia and Amaryl, you should start at the equivalent combination dose of rosiglitazone and glimepiride.
 
The first part of the rosiglitazone and glimepiride dosage refers to the rosiglitazone amount, while the second part of the dosage refers to the glimepiride amount (for example, rosiglitazone and glimepiride 4 mg/1 mg contains 4 mg rosiglitazone and 1 mg glimepiride).
 
If necessary, your healthcare provider may slowly increase your rosiglitazone and glimepiride dose to control blood sugar. The maximum dose is rosiglitazone and glimepiride 8 mg/4 mg per day.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;