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Precautions and Warnings With Rosiglitazone and Glimepiride

There are several precautions and warnings with rosiglitazone and glimepiride to be aware of, including potential allergic reactions, the risk of low blood sugar levels, and the possible risks of taking the medication while pregnant. You should not take this medication if you are allergic to any ingredient used to make the medication or if you have diabetic ketoacidosis. Be sure to tell your healthcare provider if you have any kidney or liver problems, heart problems of any kind, or if you have an upcoming surgery.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and glimepiride, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and glimepiride.
 
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.
 

Rosiglitazone and Glimepiride: What Should I Tell My Healthcare Provider?

Prior to taking rosiglitazone and glimepiride (Avandaryl®), you should talk with your healthcare provider if you have:
 
  • Kidney problems, including kidney failure or renal failure
  • Liver problems, including liver failure or cirrhosis
  • Glucose-6-phosphate dehydrogenase deficiency (G6PD deficiency) 
  • Heart problems of any kind, especially congestive heart failure (CHF)
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • An upcoming surgery
  • Any allergies, including allergies to sulfa drugs, foods, dyes, or preservatives.
     
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Having problems getting pregnant
  • Breastfeeding
  • Pre-menopausal without regular menstrual periods.
     
Also, tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
 
Common Symptoms of Diabetic Neuropathy

Rosiglitazone and Glimepiride Drug Info

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