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Drug Interactions With Rosiglitazone and Glimepiride

As with any medication, there are potential drug interactions with rosiglitazone and glimepiride. Taking this drug with other medications, such as certain decongestants, some seizure medications, and oral contraceptives, can potentially lead to problems. Some of these drug interactions can increase or decrease the level of rosiglitazone and glimepiride in your blood, potentially increasing your risk of side effects or making the drug less effective.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it was severely restricting the use of rosiglitazone and glimepiride, due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who could not control their diabetes on other medications (or those who were already taking the medication and doing well) would be able to take rosiglitazone and glimepiride.
However, in November 2013, the FDA announced that a careful analysis of the research suggests that there is not, in fact, any increased risk, compared to treatment with standard diabetes medications and that the use of this medication will no longer be restricted.

An Overview of Rosiglitazone and Glimepiride Drug Interactions

Rosiglitazone and glimepiride (Avandaryl®) can potentially interact with several medicines. Some of the medicines that may lead to rosiglitazone and glimepiride interactions include:



  • Corticosteroids, such as:


    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Orapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®


  • Diuretics, such as:





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Rosiglitazone and Glimepiride Drug Info

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