Drug Interactions With Rosiglitazone and Glimepiride

As with any medication, there are potential drug interactions with rosiglitazone and glimepiride. Taking this drug with other medications, such as certain decongestants, some seizure medications, and oral contraceptives, can potentially lead to problems. Some of these drug interactions can increase or decrease the level of rosiglitazone and glimepiride in your blood, potentially increasing your risk of side effects or making the drug less effective.

 

An Overview of Rosiglitazone and Glimepiride Drug Interactions

Rosiglitazone and glimepiride (Avandaryl®) can potentially interact with several medicines. Some of the medicines that may lead to rosiglitazone and glimepiride interactions include:
 
  • Atazanavir (Reyataz®)
     
  • Certain antifungals, including fluconazole (Diflucan®), ketoconazole (Nizoral®), and miconazole
     
  • Certain decongestants, such as phenylephrine (Sudafed PE®) or pseudoephedrine (Sudafed®)
     
  • Certain seizure medications, including:
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
  • Corticosteroids, such as:
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®) 
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
o Promethazine (Phenergan®)
(Drug Interactions With Rosiglitazone and Glimepiride Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;