Drug Interactions With Rosiglitazone and Glimepiride

As with any medication, there are potential drug interactions with rosiglitazone and glimepiride. Taking this drug with other medications, such as certain decongestants, some seizure medications, and oral contraceptives, can potentially lead to problems. Some of these drug interactions can increase or decrease the level of rosiglitazone and glimepiride in your blood, potentially increasing your risk of side effects or making the drug less effective.

In September 2010, the U.S. Food and Drug Administration (FDA) announced that it would be severely restricting the use of rosiglitazone due to the risk of "cardiovascular events" such as heart attacks and strokes. Only individuals who cannot control their diabetes on other medications (or those who are already taking the medication and doing well) will be able to take rosiglitazone.
 

An Overview of Rosiglitazone and Glimepiride Drug Interactions

Rosiglitazone and glimepiride (Avandaryl®) can potentially interact with several medicines. Some of the medicines that may lead to rosiglitazone and glimepiride interactions include:
 

 

 

  • Corticosteroids, such as:

 

    • Betamethasone (Celestone®)
    • Cortisone
    • Dexamethasone (Decadron®)
    • Fludrocortisone (Florinef®)
    • Hydrocortisone (Cortef®)
    • Methylprednisolone (Depo-Medrol®, Medrol®)
    • Prednisolone (Ovapred®, Pediapred®)
    • Prednisone
    • Triamcinolone (Kenalog®, Aristospan®) 

 

  • Diuretics, such as:

 

 

 

 

Drug Interactions With Rosiglitazone and Glimepiride Article Continues on Next Page >
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD
 
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