Drug Interactions With Rosiglitazone and Glimepiride (Cont.)

 
Phenothiazines
Taking this drug with phenothiazines can make it less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and glimepiride dose, especially when starting or stopping a phenothiazine.
 
Rifampin (Rifadin) or Rifapentine (Priftin)
Taking this drug with rifampin or rifapentine can decrease the level of rosiglitazone and glimepiride in your blood, perhaps making it less effective. Your healthcare provider may need to monitor you more closely and/or adjust your dose of these medications.
 
Ritonavir (Norvir)
Taking this drug with ritonavir can increase the level of rosiglitazone and glimepiride in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of rosiglitazone and glimepiride.
 
Thyroid Medications
Taking this drug with thyroid medications can make it less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and glimepiride dose, especially when starting or stopping a thyroid medication.
 

Final Thoughts on Rosiglitazone and Glimepiride Interactions

It is possible that not every rosiglitazone and glimepiride drug interaction was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to your situation.
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;