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Drug Interactions With Rosiglitazone and Glimepiride

Diuretics
Taking this drug with diuretics can make it less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and glimepiride dose, especially when starting or stopping a diuretic.
 
Estrogens
Taking this drug with estrogens can make it less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and glimepiride dose, especially when starting or stopping an estrogen.
 
Gemfibrozil (Lopid)
Taking this drug with gemfibrozil can increase the level of rosiglitazone and glimepiride in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of rosiglitazone and glimepiride.
 
Insulin
In studies, people taking rosiglitazone (one of the components of this medication) and insulin had an increased risk of congestive heart failure (CHF) or heart attacks. In general, it is not recommended to combine this medication with insulin.
  
Isoniazid
Taking this drug with isoniazid can make it less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and glimepiride dose, especially when starting or stopping isoniazid.
 
Niacin (Nicotinic Acid, Niaspan, Niacor, Nicolar)
Taking this drug with niacin can make it less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your rosiglitazone and glimepiride dose, especially when starting or stopping niacin.
Healthy Eating for People With Diabetes

Rosiglitazone and Glimepiride Drug Info

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