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Precautions and Warnings With Repaglinide

Precautions and warnings with repaglinide to be aware of include potential drug interactions, the risk of low blood sugar, and the danger of taking the drug when pregnant. Prior to taking it, talk to your healthcare provider about any medical conditions you may have and medications you are taking. Precautions and warnings with repaglinide also extend to people who have type 1 diabetes or diabetic ketoacidosis.

Repaglinide: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking repaglinide (Prandin®) if you have:
  • Kidney problems, including kidney failure (renal failure)
  • Liver problems, including liver failure or cirrhosis
  • Adrenal insufficiency or adrenal fatigue
  • Pituitary gland problems
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you:
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding
  • Will be having surgery.
Tell your healthcare provider about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Repaglinide

Warnings and precautions to be aware of before taking repaglinide include the following:
  • Repaglinide can cause low blood sugar (hypoglycemia), which can be dangerous. To reduce this risk, the medication should be taken only before meals. If you skip a meal, you should also skip your dose of repaglinide.
Low blood sugar is also more common in elderly people and in people with adrenal, pituitary, liver, or kidney problems, as well as during fasting before surgery and after prolonged exercise. Symptoms of low blood sugar may include:
    • Irritability
    • Trembling
    • Cold sweats
    • Blurry vision.
(Click Prandin and Blood Sugar for more information.)
  • Repaglinide is not licensed to be used with NPH insulin (Humulin® or Novolin N®). In studies, there were reports of heart problems (including heart attacks) in people who took both repaglinide and NPH insulin.
  • Fever, infections, injury, or surgery can temporarily increase blood sugar, even in people with well-controlled diabetes. Repaglinide may not be enough to treat diabetes at these times, and the use of insulin may be required. Contact your healthcare provider if you have a fever, infection, injury, or will be having surgery. Also, make sure you know the symptoms of high blood sugar and how to check your blood sugar levels.
  • Repaglinide can interact with certain medications (see Drug Interactions With Repaglinide).
  • Repaglinide is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy (see Prandin and Pregnancy for more information).
  • It is not known if repaglinide passes through breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider.
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