Drug Interactions With Repaglinide

When certain medications are combined, it is possible to have negative drug interactions. With repaglinide, problems can occur if it is taken with calcium channel blockers, certain antibiotics, or NSAIDs, for example. Your risk of low blood sugar may be increased or the level of repaglinide in your blood may be greater. If drug interactions with repaglinide are a concern, your healthcare provider may monitor you more closely or adjust your dose.

 

Drug Interactions With Repaglinide: An Introduction

Repaglinide (Prandin®) can potentially interact with other medicines. Some of the medicines that may lead to drug interactions with repaglinide include:
 
 
 
  • Certain antibiotics or antifungals, including:
 
    • Clarithromycin (Biaxin®)
    • Erythromycin (Ery-Tab®)
    • Isoniazid (Nydrazid®)
    • Itraconazole (Sporanox®)
    • Ketoconazole (Nizoral®)
    • Miconazole
    • Telithromycin (Ketek®)
    • Trimethoprim (Bactrim®, Primsol®, Septra®)
 
 
 
 
 
  • Probenecid (Benuryl®, ColBenemid®)
     
  • Protease inhibitors, such as:
 
 
  • Salicylates, such as:
 
    • Salsalate (Salflex®, Disalcid®, Amigesic®)
 
  • Sulfonamides ("sulfa drugs"), including:
 
    • Sulfadiazine
    • Sulfadoxine (Fansidar®)
    • Sulfamethoxazole (Bactrim®, Septra®)
    • Sulfisoxazole (Gantrisin®).
 
(Drug Interactions With Repaglinide Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;