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Drug Interactions With Repaglinide

Probenecid
Taking repaglinide with probenecid can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your repaglinide dose, especially when starting or stopping probenecid.
 
Protease Inhibitors
If repaglinide is combined with protease inhibitors, this can increase the level of repaglinide in your blood, which may increase your risk of side effects. Your healthcare provider may need to decrease your dose of repaglinide if you are taking these medications together.
 
Salicylates
Taking repaglinide with salicylates can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your repaglinide dose, especially when starting or stopping a salicylate.
 
Sulfonamides
If repaglinide and sulfonamides are combined, this can increase your risk of low blood sugar (hypoglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your repaglinide dose, especially when starting or stopping a sulfonamide.
 
Trimethoprim
Studies suggest that trimethoprim may increase the level of repaglinide in the blood, perhaps increasing the risk of side effects. Your healthcare provider may need to decrease your dose of repaglinide if you are taking these two medications together.
  

Final Thoughts on Drug Interactions With Repaglinide

Not all drug interactions with repaglinide were discussed in this article. For example, interactions that may make repaglinide less effective were not included. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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