Repaglinide and Metformin Dosage

Before prescribing repaglinide and metformin, a healthcare provider will consider several factors, such as how well your diabetes is controlled, whether other medical conditions are present, and if you are taking any other medications. If your starting dosage is not effective, your healthcare provider can slowly increase your dose. The maximum repaglinide and metformin dosage is 10 mg/2500 mg total per day, with a maximum dose per meal of 4 mg/1000 mg.

Repaglinide-Metformin Information

Dosage of Repaglinide and Metformin: An Introduction

Repaglinide and metformin (PrandiMet™) is a combination of two different diabetes drugs: repaglinide (Prandin^®) and metformin hydrochloride (Fortamet^®, Glucophage^®, Glucophage XR^®, Glumetza^®, or Riomet^®). The repaglinide and metformin dose that your healthcare provider recommends will vary depending on a number of factors, including:

How well your diabetes is controlled
Other medications you are taking
Any other medical conditions you may have.

As is always the case, do not adjust your dosage unless your healthcare provider specifically instructs you to do so.

Dosing for People Switching From Metformin

For people switching to repaglinide and metformin from metformin (Fortamet, Glucophage, Glucophage XR, Glumetza, or Riomet), the recommended starting dose is 1 mg/500 mg twice daily with meals. If necessary to control your diabetes, your healthcare provider may increase your dose slowly (increasing the dose quickly increases the risk of dangerously low blood sugar).

Dosing for People Switching From Prandin

For people switching to repaglinide and metformin from Prandin (repaglinide), the repaglinide and metformin dose depends on the current Prandin dose. Keeping the dose of the repaglinide component as similar as possible, the starting dose should be either repaglinide and metformin 1 mg/500 mg or 2 mg/500 mg twice a day. If necessary to control your diabetes, your healthcare provider may increase your dose slowly (increasing the dose quickly increases the risk of nausea, diarrhea, or other digestive side effects).

(Repaglinide and Metformin Dosage Continued: Page 2)