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Side Effects of Pramlintide

In clinical trials of the drug, the most commonly reported side effects of pramlintide included nausea, loss of appetite (or a decrease in food intake), and low blood sugar. Other common side effects of the medication include such things as headaches, vomiting, and fatigue. If you experience serious side effects of pramlintide, such as shortness of breath or seizures, you should report them to your healthcare provider.

Side Effects of Pramlintide: An Introduction

As with any medicine, there are possible side effects with pramlintide acetate (Symlin®). However, not everyone who takes pramlintide will experience side effects. In fact, most people tolerate the medication well. When side effects do occur with the medication, in most cases they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with pramlintide. Your healthcare provider can discuss a more complete list of pramlintide side effects with you.)

Common Side Effects of Pramlintide

Pramlintide has been studied thoroughly in clinical trials in which the side effects of a group of people taking the drug are documented and compared to another group not taking the medicine. In these studies, the most common side effects of pramlintide included:
  • Nausea -- reported in up to 48 percent of people
  • A loss of appetite or a decrease in food intake -- reported in up to 17 percent of people
  • Low blood sugar (hypoglycemia) -- reported in up to 16.8 percent of people (see Symlin and Blood Sugar)
  • Injury -- reported in up to 14 percent of people
  • Headaches -- reported in up to 13 percent of people  
  • Vomiting -- reported in up to 11 percent of people
  • Abdominal pain (or stomach pain) -- reported in up to 8 percent of people
  • Fatigue -- reported in up to 7 percent of people
  • Joint pain -- reported in up to 7 percent of people
  • Dizziness -- reported in up to 6 percent of people
  • Unexplained coughing -- reported in up to 6 percent of people
  • Allergic reactions -- reported in up to 6 percent of people
  • A sore throat -- reported in up to 5 percent of people.
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Pramlintide (Symlin)

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