Side Effects of Pioglitazone and Metformin

There are many possible side effects of pioglitazone and metformin to look out for. Common ones include swelling or fluid retention, headache, weight gain, and upper respiratory tract infections. In addition, there are potentially serious side effects of pioglitazone and metformin that may require immediate medical attention, such as symptoms of high or low blood sugar, trouble breathing, or chest pain.

 

Side Effects of Pioglitazone and Metformin: An Introduction

As with any medicine, side effects are possible with pioglitazone and metformin (Actoplus Met®). However, not everyone who takes the drug will experience side effects. In fact, most people tolerate the combination medicine quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can be easily treated by you or your healthcare provider.
 
(The side effects of pioglitazone and metformin discussed below are not a complete list of reported side effects. Your healthcare provider can discuss a more complete list with you.)
 

Common Side Effects of Pioglitazone and Metformin

Pioglitazone and metformin has been studied thoroughly in clinical trials in which side effects of a group of people taking the drug are documented and compared to another group not taking the medicine. Based on these studies, the most common side effects of pioglitazone and metformin include:
 
  • Upper respiratory tract infections (similar to the common cold or flu) -- in up to 13.5 percent of people
  • Swelling or fluid retention (edema) of the lower leg or ankles -- up to 11.3 percent
  • Weight gain -- up to 6.7 percent (see Actoplus Met and Weight Gain)
  • Diarrhea -- up to 5.8 percent
  • Nausea -- up to 5.8 percent
  • Urinary tract infections (UTIs), including bladder infections -- up to 5.8 percent
  • Dizziness -- up to 5.4 percent
  • Headache -- up to 5.3 percent
  • Sinus infection or irritation -- up to 5 percent.
     
(Side Effects of Pioglitazone and Metformin Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;