Side Effects of Pioglitazone and Metformin (Cont.)

Serious Side Effects of Pioglitazone and Metformin

Some side effects of pioglitazone and metformin, while uncommon, should be reported to your healthcare provider. These include but are not limited to:
 
  • Signs of lactic acidosis. These are a result of the metformin component of pioglitazone and metformin, and include:
 
    • Feeling tired or weak
    • Muscle pain
    • Trouble breathing
    • Stomach pain
    • Feeling cold, dizziness, or lightheadedness
    • Slow or irregular heartbeat (see Metformin and Lactic Acidosis).
 
  • Symptoms of high blood sugar, including:
 
    • Increased hunger
    • Increased thirst
    • Increased urination
    • Blurred vision
    • Fatigue
    • Shortness of breath
    • Nausea or vomiting.
 
  • Symptoms of low blood sugar, including:
 
    • Sweating
    • Shakiness
    • Extreme hunger
    • Dizziness
    • Cold sweats
    • Blurry vision
    • Changes in behavior, such as irritability
    • Loss of coordination
    • Difficulty speaking
    • Confusion
    • Seizures.
 
  • Chest pain.
 
 
  • Swelling, especially in the legs or ankles.
 
  • Rapid increase in weight (three to five pounds in less than one week).
 
  • Liver problems, including:
 
    • Nausea or vomiting
    • Stomach pain
    • Unusual or unexplained tiredness
    • Loss of appetite
    • Dark urine
    • Yellowing of your skin or the whites of your eyes.
 
  • Vision changes.
 
  • Signs of an allergic reaction, including:
 
    • Unexplained skin rash
    • Itching
    • Hives
    • Wheezing or trouble breathing
    • Unexplained swelling.
 
(Side Effects of Pioglitazone and Metformin Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;