Precautions and Warnings With Pioglitazone and Metformin (Cont.)

Who Should Not Take Pioglitazone and Metformin?

You should not take pioglitazone and metformin if you:
 
  • Are allergic to pioglitazone hydrochloride (Actos®), metformin hydrochloride (Fortamet®, Glucophage®, Glucophage XR®, Glumetza®, or Fortamet®), or any inactive component used to make pioglitazone and metformin. Your healthcare provider or pharmacist has a list of the inactive ingredients.
     
  • Have kidney disease, including kidney failure (renal failure).
     
  • Have metabolic or diabetic ketoacidosis (a life-threatening condition that may occur with uncontrolled diabetes). This condition needs to be treated with insulin.
     
  • Are seriously dehydrated (have lost a lot of water from your body).
     
  • Are going to have an x-ray procedure with injection of dyes (contrast agents).
     
  • Are going to have surgery.
     
  • Develop a serious condition, such as heart attack, severe infection, or a stroke.
     
  • Are 80 years old or older and you have not had your kidney function tested.

 

Precautions and Warnings With Pioglitazone and Metformin: A Summary

There are a number of situations in which pioglitazone and metformin should not be taken, as well as several precautions and warnings people should be aware of before starting the drug. However, it is possible that not all warnings or precautions were discussed in this article. Therefore, you should talk with your healthcare provider about any precautions and warnings with pioglitazone and metformin that may apply to you.
 
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;