Drug Interactions With Pioglitazone and Metformin

When various medications are taken simultaneously, drug interactions may potentially develop. With pioglitazone and metformin, these interactions can ultimately lead to increased or decreased drug levels in your system, reduced effectiveness of the medicines, or high blood sugar. Medications that may cause drug interactions with pioglitazone and metformin include: atorvastatin, diuretics, phenothiazine medications, and calcium channel blockers.

Drug Interactions With Pioglitazone and Metformin: An Overview

Pioglitazone and metformin (Actoplus Met®) can potentially interact with several different drugs. Some of the medicines that can lead to drug interactions with pioglitazone and metformin include:
 
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Betamethasone (Celestone®)
o Cortisone
o Dexamethasone (Decadron®)
o Fludrocortisone (Florinef®)
o Hydrocortisone (Cortef®)
o Methylprednisolone (Depo-Medrol®, Medrol®)
o Prednisolone (Ovapred®, Pediapred®)
o Triamcinolone (Kenalog®, Aristospan®)
  • Diuretics, such as:
o Acetazolamide (Diamox®)
o Chlorthalodone
  • Rifampin (Rifadin®) or rifapentine (Priftin®)
     
  • Ritonavir (Norvir®)
     
  • Thyroid medications, such as:
 
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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