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Drug Interactions With Pioglitazone and Metformin

Rifampin or Rifapentine
If pioglitazone and metformin is taken with rifampin or rifapentine, it can decrease the level of pioglitazone and metformin in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of pioglitazone and metformin to prevent this interaction from occurring.
 
Ritonavir
Taking pioglitazone and metformin with ritonavir can increase the level of pioglitazone and metformin in your blood, increasing your risk of side effects. As a result, your healthcare provider may need to decrease your dose of pioglitazone and metformin.
 
Thyroid Medications
Taking pioglitazone and metformin with thyroid medications can make pioglitazone and metformin less effective, possibly increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping a thyroid medication.
 

Drug Interactions With Pioglitazone and Metformin: Final Thoughts

It is possible that not all drug interactions with pioglitazone and metformin were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
 
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Pioglitazone and Metformin (Actoplus Met)

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