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Drug Interactions With Pioglitazone and Metformin

Gemfibrozil
Combining pioglitazone and metformin with gemfibrozil can increase the level of pioglitazone and metformin in your blood, which can increase your risk of side effects. Your healthcare provider may need to decrease your dose of pioglitazone and metformin to prevent this interaction.
 
Isoniazid
Taking pioglitazone and metformin with isoniazid can make pioglitazone and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping isoniazid.
 
Niacin
Taking pioglitazone and metformin with niacin can make pioglitazone and metformin less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping niacin.
 
Oral Contraceptives
Combining pioglitazone and metformin with oral contraceptives (birth control pills) can make pioglitazone and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). To prevent this, you may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping an oral contraceptive.
 
Phenothiazines
Combining pioglitazone and metformin with phenothiazines can make pioglitazone and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping a phenothiazine.
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