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Drug Interactions With Pioglitazone and Metformin

Cimetidine
Taking pioglitazone and metformin with cimetidine can increase the level of pioglitazone and metformin in your blood, increasing your risk of side effects. Your healthcare provider may need to adjust your dose of these medications or suggest an alternative to cimetidine, depending on your particular situation.
 
Corticosteroids
If pioglitazone and metformin is taken with corticosteroids, this can make pioglitazone and metformin less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping a corticosteroid.
 
Diuretics
Taking pioglitazone and metformin with diuretics can make pioglitazone and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping a diuretic.
 
If pioglitazone and metformin are taken with furosemide (a diuretic), this can affect the levels of these drugs in your blood. This may increase your risk of pioglitazone and metformin side effects and make furosemide less effective. To prevent this interaction, your healthcare provider may need to adjust your dose of these medications.
 
Estrogens
Taking pioglitazone and metformin with estrogens can make pioglitazone and metformin less effective, potentially increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping an estrogen.
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Pioglitazone and Metformin (Actoplus Met)

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