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Drug Interactions With Pioglitazone and Metformin

Interactions With Pioglitazone and Metformin Explained

The following sections explain in detail the potentially negative interactions that can occur when pioglitazone and metformin are combined with any of the drugs listed above.
 
Atazanavir
Taking pioglitazone and metformin with atazanavir can increase the level of pioglitazone and metformin in your blood, possibly increasing your risk of side effects. Your healthcare provider may need to decrease your dose of pioglitazone and metformin to prevent this interaction.
 
Atorvastatin
In studies, taking pioglitazone and metformin with atorvastatin decreased the levels of both medications in the blood, perhaps making them less effective. To prevent this, your healthcare provider may need to adjust your dose of these medications.
 
Calcium Channel Blockers
Combining pioglitazone and metformin with calcium channel blockers can make pioglitazone and metformin less effective, increasing your chance of high blood sugar (hyperglycemia). You may need to be monitored more closely, and your healthcare provider may need to adjust your pioglitazone and metformin dose, especially when starting or stopping a calcium channel blocker.
 
Decongestants
Taking pioglitazone and metformin with certain decongestants can make pioglitazone and metformin less effective, potentially increasing your chance of high blood sugar (hyperglycemia). Decongestants are in many cough and cold products, so be sure to talk to your healthcare provider before taking any cough or cold products if you are taking pioglitazone and metformin.
 
Seizure Medications
Combining pioglitazone and metformin with certain seizure medications can decrease the level of pioglitazone and metformin in your blood, perhaps making it less effective. Your healthcare provider may need to increase your dose of pioglitazone and metformin to prevent this interaction from occurring.
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