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Side Effects of Pioglitazone and Glimepiride

Common side effects of pioglitazone and glimepiride include headache, fluid retention, and upper respiratory tract infections. Most side effects -- if they occur -- are mild and either do not require treatment or can be treated easily. Some pioglitazone and glimepiride side effects, however, should be reported to your healthcare provider immediately, such as symptoms of low blood sugar, rapid weight gain, or vision changes.

Side Effects of Pioglitazone and Glimepiride: An Introduction

As with any medicine, side effects are possible with pioglitazone and glimepiride (Duetact®). However, not everyone who takes the medicine will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with pioglitazone and glimepiride. Your healthcare provider can discuss a more complete list of pioglitazone and glimepiride side effects with you.)

Serious Pioglitazone and Glimepiride Side Effects

Some side effects of pioglitazone and glimepiride, while uncommon, should be reported to your healthcare provider. These include but are not limited to:
  • Symptoms of bladder cancer, such as:
    • Blood in the urine
    • Urgent need to urinate
    • Pain while urinating
    • Pain in the back or lower abdomen (stomach)
  • Symptoms of low blood sugar, such as:
    • Sweating
    • Shakiness
    • Extreme hunger
    • Dizziness
    • Cold sweats
    • Blurry vision
    • Changes in behavior, such as irritability
    • Loss of coordination
    • Difficulty speaking
    • Confusion
    • Seizures
  • Trouble breathing (which may be a sign of new or worsening congestive heart failure)
  • Swelling, especially in the legs or ankles
  • Rapid increase in weight (three to five pounds or more in less than one week)
  • Liver problems, such as:
    • Nausea or vomiting
    • Stomach pain
    • Unusual or unexplained tiredness
    • Loss of appetite
    • Dark urine
    • Yellowing of your skin or the whites of your eyes (jaundice)
  • Vision changes
  • Signs of an allergic reaction, such as:
    • Unexplained skin rash
    • Itching
    • Hives
    • Wheezing or trouble breathing
    • Unexplained swelling.
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Pioglitazone and Glimepiride Info

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